EPA-1
Extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway
1iPS Cell Advanced Characterization and Development Team, Riken BRC, 2Graduate School of Comprehensive Human Science, Laboratory of Regenerative Medicine and Stem Cell Biology, University of Tsukuba, 3Department of Computer Science, University of Tsukuba, 4Department of Obstetrics and Gynecology, University of Tsukuba, 5Department of Cardiovascular Surgery, University of Tsukuba
○Yun-Hsuan Chang1,2, Cat-Khanh Vuong2, Nhat-Hoang Ngo2, Toshiharu Yamashita2, Xiucai Ye3, Yasunori Futamura3, Mizuho Fukushige2 , Mana Obata-Yasuoka4, Hiromi Hamada4, Motoo Osaka5, Yuji Hiramatsu5 , Tetsuya Sakurai3, Osamu Ohneda1

EPA-2
Generation of cell models with Gasdermin D mutation responsible for atypical osteolytic Gorham-Stout disease
1Graduate School of Pharmaceutical Sciences, Tokyo University of Sicence, 2Department of Joint Surgery and Sports Medicine,TMDU, 3Teikyo Heisei University
○Kanon Otsuka1, Yasuhiro Arasaki1, Yukihiro Kohara1, Yoichi Ezura2,3, Tadayoshi Hayata1

EPA-3
Establishment of human iPS cell lines derived from NF1 patients to elucidate the mechanism of malignant transformation of neurofibromas
1Dept. of Reg. Sci. Okayama Univ. Grad. Sch., Med. Dent. & Pharm. Sci., 2Dept. of OrS. Okayama Univ. Grad. Sch., Med. Dent. & Pharm. Sci., 3Dept. of CIG. Okayama Univ. Grad. Sch., Med. Dent. & Pharm. Sci.
○Taro Osawa1, Eiji Nkata2, Masayuki Okamoto1, Daisuke Yamada1, Mashu Futagawa3, Tomoka Takao1, Akira Hirasawa3, Toshifumi Ozaki2, Takeshi Takarada1

EPA-4
Elucidating pathogenesis of Wolf-Hirschhorn syndrome using patient-derived human induced pluripotent stem cells
1iPS Cell Advanced Characterization and Development Team, BioResource Research Center, RIKEN 2Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Sciences, The University of Tokyo, 3Cell Engineering Division, BioResource Research Center, RIKEN
○Tomoya Shimizu1,2 Mami Matsuo-Takasaki1, Miho Takami1, Michiya Noguchi3, Yukio Nakamura3, Tadayoshi Hayata2, Yohei Hayashi1

EPA-5
Identification of cell competition markers
1Division of Cancer Cell Biology, Research Institute for Biomedical Sciences, Tokyo University of Science, 2Associate Professor at Center for Molecular medicine, Jichi Medical University, 3Division of Collaborative Research and Developments, Exploratory Oncology Research & Clinical Trial Center, Nationcal Cancer Center
○Olivia Marchia Kusuma1, Eilma Akter1, Takahiro Kuchimaru2, Kazuki Nakai1,3, Shunsuke Kon1

EPA-7
Generation of human induced pluripotent stem cell line four Rett syndrome patients with MECP2 mutation
1iPS Cell Advanced Characterization and Development Team, BioResource Research Center, RIKEN, 2Department of Materials Science and Bioengineering, Nagaoka University of Technology, 3Department of Pediatrics, Graduate School of Medicine, Chiba University, 4Cell Engineering Division, BioResource Research Center, RIKEN, 5Department of Science of Technology Innovation, Nagaoka University of Technology
○Miyu Mori1,2, Shoko Yoshii3, Michiya Noguchi2, Yukio Nakamura2, Satoru Takahashi4, Hiromichi Hamada3, Kiyoshi Ohnuma5, Tadashi Shiohama3, Yohei Hayashi1

EPA-8
Study no a novel molecular mechanism of mesothelioma progression that is triggered by activation of Ca2+ channel
1Okayama University, 2Kansai Medical University, 3Kawasaki Medical University
○Nahoko Tomonobu1, Yuma Gohara1, Ken-ichi Yamamoto1, Rie Kinoshita1, Hitoshi Murata1, Eisaku Kondo2, Shinichi Toyooka1, Akira Yamauchi3, Masahiro Nishibori1, Masakiyo Sakaguchi1

EPA-1
TLR4 accelerates bladder cancer progression upon interaction with S100A8/A9
1 Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci., 2 Kawasaki Med. Sch.
○Fan Jiang1, Acosta Gonzalez Herik Rodrigo1, Nahoko Tomonobu1, Rie Kinoshita1, Yuma Gohara1, Ni Luh Gede Yoni Komalasari1, Ken-ichi Yamamoto1, Hitoshi Murata1, Akira Yamauchi2, Shinichi Toyooka1, Masami Watanabe1, Yasutomo Nasu1, Masakiyo Sakaguchi1

EPA-2
Production of hyaline cartilage sheet using human induced pluripotent stem cell-derived chondrocyte precursor cells
1Dept. Regenerative Science, Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci., 2Dept. Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 3Dept. Orthopedic Surgery, Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci.
○Tomoka Takao1, Masato Sato2, Eriko Toyoda2, Yuki Fujisawa1, Daisuke Yamada1, Eiji Nakata3, Toshifumi Ozaki3, Takeshi Takarada1

EPA-3
Establishment of an inflammatory bowel disease model using human iPS cell-derived colonic epithelial cells
1Center for iPS Cell Research and Application (CiRA), Kyoto University, 2AMED-CREST
○Fuki Yokoi1, Sayaka Deguchi1, Kazuo Takayama1,2

EPA-1
Lysyl oxidase-like 4 is prominent in breast cancer progression through its enzymatic activities
1Okayama University, 2Gunma University
○Ni Luh Gede Yoni Komalasari1, Nahoko Tomonobu1, Fan Jiang1, Acosta Gonzalez Herik Rodrigo1, Yuma Gohara1, Ken-ichi Yamamoto1, Rie Kinoshita1, Hitoshi Murata1, Yusuke Inoue2, Masakiyo Sakaguchi1

EPA-2
REIC protein suppresses tumor progression through PD-L1 regulation in cancer cells
1Okayama University, 2Niimi University
○Yuma Gohara1, Nahoko Tomonobu1, Rie Kinoshita1, Hitoshi Murata1, Ken-ichi Yamamoto1, Masayoshi Namba1, Nam-ho Huh1, Hiromi Kumon2, Masakiyo Sakaguchi1

EPA-3
The differentiation dotency of human liver organoids towards biliary epithelial cells
1Grad. Sch. of Pharm. Sci., Osaka Univ., 2NIBIOHN, 3OTRI, Osaka Univ., 4MEI cent., Osaka Univ.
○Yanran Tong1, Yukiko Toba1-3, and Hiroyuki Mizuguchi1-4

EPA-4
Elucidation of COVID-19 pathophysiology using liver-on-a-chip
1Center for iPS Cell Research and Application (CiRA), Kyoto University, 2Graduate School of Medicine, Kyoto University, 3College of Pharmaceutical Sciences, Ritsumeikan University, 4Institute for Frontier Life and Medical Sciences, Kyoto University, 5JST-CREST, 6Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, 7Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), 8Department of Micro Engineering, Kyoto University, 9AMED-CREST
○Sayaka Deguchi1, Kaori Kosugi1, Rina Hashimoto1, Ayaka Sakamoto1, Masaki Yamamoto2, Ryosuke Negoro3, Takeshi Noda4,5, Takuya Yamamoto1,6,7, Yu-suke Torisawa8, Miki Nagao2, Kazuo Takayama1,9

EPA-5
Comparison of culture media for human enteroids from the viewpoint of pharmacokinetic studies
1Grad. Sch. of Pharm. Sci., Osaka Univ., 2Natl. Inst. of Biomed. Innov. Health and Nutrition, 3Nippon Boehringer Ingelheim Co., Ltd., 4Sapporo Med. Univ., 5Inst. for Open and Transdisciplinary Res. Initiatives, Osaka Univ., 6Global Ctr. for Med. Eng. and Informatics, Osaka Univ.
○Jumpei Yokota1,2, Tomoki Yamashita1, Tatsuya Inui1,2, Wataru Kishimoto3, Hiroshi Nakase4, Hiroyuki Mizuguchi1,2,5,6

EPA-6
Establishment of hepatocyte organoids using human iPS cell-derived hepatocytes and their investigation for drug discovery research
1Grad. Sch. of Pharm. Sci., Osaka Univ., 2Natl. Inst. of Biomed. Innov. Health and Nutrition, 3Global Ctr. for Med. Eng. and Informatics, Osaka Univ., 4Inst. for Open and Transdisciplinary Res. Initiatives, Osaka Univ.
○Jumpei Inui1, Yukiko Toba1,2,3, and Hiroyuki Mizuguchi1,2,3,4

EPA-1
Novel Cyclic N-alkyl Peptide Dimers as bFGF Mimetics to Maintain the Pluripotency of Human Induced Pluripotent Stem Cells
1Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 2Advanced Biotechnology Center, University of Yamanashi
○Masashi Sato1, Yoshitsugu Ohnuki1, Shinji Masui1,2, Takashi Kawakami1 and Hiroshi Kurosawa1

EPA-2
Human cell culture based characterization of antistress and antiaging activities in Lipoic Acid
1AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), Cellular and Molecular Biology Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), 2School of Integrative and Global Majors, University of Tsukuba, 3CycloChem Bio Co., Ltd., 4KAUL-Tech Co., Ltd.
○Ashish Kaul1,2, Yoshiyuki Ishida3, Keiji Terao3, Renu Wadhwa1.2, Sunil C. Kaul1,4

EPA-3
Identification of tectorigenin as a hypoxia-inducing phytochemical: potentials in laboratory and clinic
1AIST-INDIA DAILAB, DBT-AIST International Centre for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), 2Life Science Innovation, School of Integrative and Global Majors, University of Tsukuba
○Mallika Khurana1,2, Sunil C. Kaul1, Renu Wadhwa1,2

EPA-4
Effect of Ashwagandha extracts on muscle cell differentiation
1AIST-INDIA DAILAB, DBT-AIST International Center for Translational & Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), 2Graduate School of Science & Technology, University of Tsukuba
○Huayue Zhang1,2, Jia Wang1, Sunil C. Kaul1 and Renu Wadhwa1

EPA-5
Evaluation of the anticancer activities of Mortaparibmild, a novel agent with p53-dependent and -independent mechanism
1AIST-INDIA DAILAB, National Institute of Advanced Industrial Science & Technology (AIST), 2School of Integrative & Global Majors (SIGMA), University of Tsukuba, 3DAILAB, Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology (IIT) Delhi
○Hazna Noor Meidinna1,2, Anissa Nofita Sari1,2, Priyanshu Bhargava1, Seyad Shefrin3, Durai Sundar3, Sunil C. Kaul1 and Renu Wadhwa1,2

EPA-6
PDGFR alpha and beta regulate cell proliferation in malignant mesothelioma
1Department of Genomic Oncology and Oral Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 2Department of Medical System Engineering, Graduate School of Biomedical and Health Sciences, Hiroshima University, 3Department of Oral Biology & Engineering, Graduate School of Biomedical and Health Sciences, Hiroshima University
○Tomoya Suehiro1、Nguyen Truong Duc Hoang1、Yuichi Mine2、Hiroki Nikawa3、Makiko Fujii1

EPA-7
Identification of novel biomarker Myoferlin, by dissecting oxaliplatin-resistant gastric cancer organoid
1Dept. Mol. Path., Hiroshima Univ., 2Dept. Health Care for Adults, Hiroshima Univ., 3Dept. Gastroenterological and Transplant Surg., Hiroshima Univ.
○Kenji Harada1, Naoya Sakamoto1, Shoichi Ukai1, Daiki Taniyama1, Ryota Maruyama1, Tsuyoshi Takashima1, Kazuaki Tanabe2, Hideki Ohdan3, and Wataru Yasui1

EPA-1
Identification of a novel small molecule that abrogates mortalin-p53 interaction in luminal-A breast cancers
1 DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), 2 School of Integrative & Global Majors, University of Tsukuba, 3 CycloChem Co., Ltd.a
○Ahmed Elwakeel1,2, Anissa Nofita Sari1,2, Renu Wadhwa1,2 and Sunil Kaul1,2

EPA-1
Marine carotenoids, Astaxanthin and Fucoxanthin have antistress and protein deaggregation activities
1 DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), 2 School of Integrative & Global Majors, University of Tsukuba, 3 CycloChem Co., Ltd.a
○Sajal Afzal1,2, Sukant Garg1, Yoshiyuki Ishida3, Keiji Terao3, Renu Wadhwa1,2 and Sunil C. Kaul1

EPA-2
Inhibition of PARP-1 and DNA repair by Withaferin A and CAPE induces apoptosis in cervical cancer cells
1 DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), 2 School of Integrative & Global Majors, University of Tsukuba, 3 CycloChem Co., Ltd.
○Anissa Nofita Sari1,2, Priyanshu Bhargava1, Yoshiyuki Ishida3, Keiji Terao3, Sunil C. Kaul1, and Renu Wadhwa1

EPA-3
Development of testis structure in vitro and its application to toxic assays
Graduate School of Nanobioscience, Yokohama City University
○Takeshi Akama and Nobuhiko Kojima

EPA-1
Integration of conventional cell viability assays- recruiting reliable and reproducible read-outs
Drug Discovery and Assets Innovation Lab (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki 305 8565, Japana
○Sukant Garg, Sunil Kaul and Renu Wadhwa

EPA-1
Mortalin contributes to cancer cell stemness: molecular evidence to its role in drug resistance
1DAILAB, National Institute of Advanced Industrial Science & Technology, Tsukuba - 305 8565; 2Graduate School of Life & Environmental Sciences, University of Tsukuba
○Priyanshu BHARGAVA1,2, Motomichi DOI1,2, Sunil KAUL1, Renu WADHWA1

EPA-1
Optimization of precise genome editing in human induced pluripotent stem cells
Department of Pediatrics, Graduate School of Medicine, Osaka University
○Kimihiko BANNO, Yasuji KITABATAKE, Sayaka OMORI, Katsuya HIRATA, Keiichi OZONO

EPA-2
Loss-of-Function Screening For Regulators of Melanogenesis: Identification of Role of Mortalin in Pigmentation
1.DAILAB, AIST, Tsukuba, 2.University of Tsukuba, 3.KK Chanel Research & Technology Development Lab, Funabashi
○Ling LI1,2, Nobuhiro ANDO3, Christian MAHE3, Sunil C. KAUL1 and Renu WADHWA1

EPA-1
Dynamic Expression of B7 Family Molecules on Hematopoietic Stem Cells.
1.Immunobiology and Cancer Program, Oklahoma Medical Research Foundation,Oklahoma City, OK, USA
2.Laboratory of Cell Cultures, National Institute of Biomedical Innovation,Ibaraki, Osaka, Japan
○Ryuji IIDA1,2, Karla P. GARRETT1, Tomoyuki SHIMAZU1, José ALBEROLA-LLA1, Arihiro KOHARA2, and Paul W. KINCADE1

EPA-2
Role of vasopressin receptor (V1b) in the formation of neurites in PC12 cells.
Department of Pharmacology, National Research Institute for Child Health and Development
○Kyaw Htet AUNG, Kazuaki NAKAMURA, Akito TANOUE

EPA-3
CARF determines proliferative fate of cell by a two-way regulation of DNA damage and growth arrest signaling.
Cell proliferation Research Group, National Institute of Advanced Industrial Science & Technology (AIST)
○Rajkumar Singh KALRA, Sunil KAUL and Renu WADHWA

EPA-4
3β-methoxy-Withaferin A lacks anticancer potency.
Cell proliferation Research Group, National Institute of Advanced Industrial Science & Technology (AIST)
○Anupama CHAUDHARY, Chuan HUANG, Renu WADHWA, and Sunil KAUL