１． 氏名：
	山田正篤　　（やまだ　まさあつ）
２． 略歴：
	１） 生年月日、生誕地 ・ 大正１４年９月２６日、東京都　生まれ ２） 学歴（高校以降） ・ 昭和１９年９月　東京高校　卒業 ・ 昭和２３年９月　東京大学医学部　卒業 ３） 職歴（主なもの） ・ 昭和２４年１２月　東京大学付属伝染病研究所研究生 ・ 昭和２６年１月　東京大学医学部小児科学教室研究生 ・ 昭和２８年７月　国立予防衛生研究所厚生技官 ・ 昭和３５年２月　アメリカ合衆国コロラド大学医学部生物物理学教室へ留学 ・ 昭和３６年１１月　国立予防衛生研究所病理部細胞病理室長 ・ 昭和４４年９月　東京大学薬学部教授（生理化学講座担当） ・ 昭和５６年４月　東京大学薬学部長 ・ 昭和６１年３月　定年退官 ・ 昭和６１年４月　�鞄�本たばこ医薬事業部顧問 ・ 昭和６１年５月　食品薬品安全センター顧問 ４） 培養学会での役職 ・ 会長（昭和５７年４月〜昭和５９年３月）
３． 業績：	研究テーマの年譜と主な業績（特に培養を用いたもの）
	１）　DNA複製：その機構と関連酵素 Yamada M., Hanaoka F: Periodic changes in the association of mammalian DNA with the membrane during the cell cycle. Nature New Biol., 243, 227-230, 1973.　(uids=4268557) Sekiguchi T, Sekiguchi F, Yamada M: Incorporation and replication of foreign metaphase chromosomes in cultured mammalian cells. Exp. Cell Res., 80, 223-226, 1973. (uids=4361347) Kohwi-Sigematsu T, Enomoto T, Yamada M: Exposure of DNA bases induced by the interaction of DNA and calf thymus DNA helix-destabilizing protein. Proc.Nat.Acad.Sci.USA, 75,4689-4693, 1978. (uids=216994) Enomoto T, Tanuma S, Yamada M: Characterization of deoxyribonucleic acid synthesis in reconstituted nuclear systems, Biochemistry, 22, 1128-1133, 1983. (uids=6838842) Enomoto T, Tanuma S, Yamada M: Purification and characterization of two forms of DNA polymerase α from HeLa cell nuclei, Biochemistry, 22, 1134-1138, 1983. (uids=6838843) Tawaragi Y, Enomoto T, Watanabe Y, Hanaoka F, Yamada M: Multiple deoxyribonucleic acid dependent adenosinetriphosphatases in FM3A cells. Characterization of an adenosinetriphosphatase that prefers poly[d(A-T)] as cofactor, Biochemistry, 23,529-533, 1984. (uids=6142725) Murakami Y, Yasuda H, Miyazawa H, Hanaoka F, Yamada M: Characterization of a temperature-sensitive mutant of mouse FM3A cells defective in DNA replication, Proc. Nat. Acad. Sci. USA, 82, 1761-1765, 1985. (uids=3856858) Hanaoka F, Tandai M, Miyazawa H, Murakami Y., Hori T, Yamada M: Human DNA polymerase α: compensation for heat-labile mouse DNA polymerase α and its gene localization on the X chromosome, Mol. Biol. Med., 2, 323-335, 1985. (uids=6545382) Seki M, Enomoto T, Watanabe Y, Tawaragi Y, Kawasaki K, Hanaoka F, Yamada M: Purification and characterization of a deoxyribonucleic acid dependent adenoinetriphosphatase from mouse FM3A cells:　effects of ribonucleoside triphosphatses on the interaction of the enzyme with single-stranded DNA, Biochemistry, 25, 3239-3245, 1986. (uids=3015201) Kawasaki K, Enomoto T, Suzuki M, Seki M, Hanaoka F, Yamada M: Detection of a novel factor which stimulates DNA polymerase α in mouse FM3A cell extract, Biochemistry, 25, 3044-3050, 1986. (uids=3718939) Eki T, Murakami Y, Enomoto T, Hanaoka F, Yamada M: Characterization of DNA replication at a restrictive temperature in a mouse DNA ts mutant, tsFT20 strain, containing heat-labile DNA polymerizing activity, J. Biol. Chem., 261, 8888-8893, 1986. (uids=3722180) Murakami Y, Eki T, Yamada M, Prives C, Hurvitz J: Species-specific in vitro synthesis of DNA containing the polyoma virus origin of replication, Proc. Nat. Acad. Sci. USA, 83, 6347-6351, 1986. (uids=3018726) 　 ２） ＤＮＡ修復 Kato H, Hanaoka F, Nishimura T, Yamada K, Yamada M: DNA repair synthesis in HeLa cell lysate, Biochem. Biophys. Acta, 606, 47-56, 1980. (uids=7353017) Yamada K, Hanaoka F, Yamada M: Effects of aphidicolin and/or 2',3'-dideoxythymidine on DNA repair induced in HeLa cells by four types of DNA-damaging agents, J. Biol. Chem., 260, 10412-10417, 1985. (uids=2411723) Otsuka F. Yamada K, Ohno H, Enomoto T, Hanaoka F, Ohsawa M, Yamada M: Effect of 3-aminobenzamide on the process of ultraviolet-induced DNA excision repair, Mutation Res., 161, 75-82, 1986. (uids=3702897) ３） 染色体の構造と染色体タンパク Tanuma S, Enomoto T, Yamada M: Effect of thymidine on poly(ADP-ribosyl)ation in vitro, J. Biol. Chem., 254, 4960-4962, 1979. (uids=156179) Mita S, Yasuda H, Marunouchi T, Ishiko S, Yamada M: A temperature-sensitive mutant of cultured mouse cells defective in chromosome condensation, Exp. Cell Res., 126, 407-416, 1980. (uids=6153988) Matsumoto Y, Yasuda H, Mita S, Marunouchi T, Yamada M: Evidence for the involvement of H1 histone phosphorylation in chromosome condensation, Nature, 284, 181-183, 1980. (uids=7360244) Ishimi Y, Yasuda H, Ohba Y, Yamada M: The reassociation with chromatin of H1 fragments bisected with thrombin, J. Biol. Chem, 256, 8249-8251, 1981. (uids=7263648) Yasuda H, Matsumoto Y, Mita S, Marunouchi T, Yamada M: A mouse temperature-sensitive mutant defective in H1 histone phosphorylation is defective in deoxyribonucleic acid synthesis and chromosome condensation, Biochemistry, 20, 4414-4419, 1981. (uids=7284331) ４） 細胞老化 Mitsui Y, Sakagami H, Murota, S, Yamada M: Age-related decline in histone H1 fraction in human diploid fibroblasts, Exp. Cell Res., 126, 289-298, 1980. (uids=7363946) Hasegawa N, Hanaoka F, Hori T, Yamada M: Reevaluation of DNA chain elongation rate in human diploid fibroblasts, Exp. Cell Res., 140,443-447, 1982. (uids=7117404) Hanaoka F, Takeuchi F, Matsumura T, Goto M, Miyamoto T, Yamada M: Decrease in the average size of replicons in a Werner syndrome cell line by Simian Virus 40 infection, Exp. Cell Res., 144, 463-467, 1983. (uids=6301867) Hasegawa N, Hanaoka F, Yamada M: Does capacity of DNA replication change during in vitro ageing?, Exp. Cell Res., 156, 478-486, 1985. (uids=3967689) ５）　細胞培養、細胞周期 Yamada M. Puck T T: Action of radiation on mammalian cells. �W. Reversible mitotic lag in the S3 HeLa cell produced by low doses of X-rays, Proc. Nat. Acad. Sci. USA, 47, 1181-1191, 1961. Yoshikura H, Hirokawa Y, Yamada M: Synchronized cell division induced by medium change, Exp. Cell Res., 48, 226-228, 1967. (uids=4168505) Tanuma S, Enomoto T, Yamada M: Changes in the level of poly ADP-ribosylation during a cell cycle, Exp. Cell Res., 117, 421-430, 1978. (uids=31293) Yasuda H, Hanai N, Kurata M, Yamada M: Cyclic GMP metabolism in relation to the regulation of cell gowth in BALB/c3T3 cells, Exp. Cell Res., 114, 111-116, 1978. (uids=26583)
４． 座右の銘
５． 後進に一言
	自分で掴んだテーマをどこまでも離さないで、楽しんで研究すること。
6. 特記事項
	平成17年12月16日　逝去 (追悼文掲載：鈴木崇彦先生　機関誌「組織培養研究」第25巻2号）